Professor Adrian Krainer.
In the full case of the RNA transcript for PK-M RNA, the choice is normally between two exons: exon 9, found in PK-M1; and exon 10, whose inclusion results in PK-M2 production. In this research, our goal was to determine what the splicing machinery searches for when it’s trying to choose which exon to include and which exon to exclude, specifies Krainer. Carrying out a series of experiments in which the team manipulated the two exons within a precursor type of the RNA PK-M by duplicating them, swapping their positions, etc., the scientists discovered that the signals for exclusive splicing reside within the two exons themselves mutually.There is absolutely no treatment, and affected cattle die.
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